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For U.S. Residents Only
Important Safety Information

Your Guide to
ZALTRAP® (ziv-aflibercept)

ZALTRAP, a vascular endothelial growth factor inhibitor, in combination with fluorouracil, leucovorin, irinotecan (FOLFIRI), is indicated for the treatment of patients with metastatic colorectal cancer that is resistant to or has progressed following an oxaliplatin-containing regimen.

You or a loved one may be considering therapy with ZALTRAP, also known as ziv-aflibercept, which is an FDA-approved anti-cancer medicine given in combination with a chemotherapy regimen called FOLFIRI (foal-feer-ee) to treat colorectal cancer that has spread. FOLFIRI combines the drugs fluorouracil, leucovorin, and irinotecan. ZALTRAP is an option for people who have had their cancer worsen or have become resistant to the initial therapy used to treat their metastatic colorectal cancer (mCRC).

Those who receive ZALTRAP have been previously treated with a chemotherapy called oxaliplatin (ox-alley-plaht-in).

IMPORTANT SAFETY INFORMATION

Patients treated with ZALTRAP have experienced serious side effects. Your doctor may adjust or stop your ZALTRAP treatment if you have these or other side effects:

Before Receiving ZALTRAP, Tell Your Doctor If You:

The most common side effects of ZALTRAP include:

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of ZALTRAP. For more information, ask your doctor or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.

Please see full Prescribing Information.

In the U.S., ZALTRAP is a registered trademark of Regeneron Pharmaceuticals, Inc.

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MAT-US-2008717 Last Update: May 2020

ZALTRAP was developed in collaboration with Regeneron Pharmaceuticals, Inc.

This site is intended for U.S. audiences only.

IMPORTANT SAFETY INFORMATION

Patients treated with ZALTRAP have experienced serious side effects. Your doctor may adjust or stop your ZALTRAP treatment if you have these or other side effects:

  • Severe Bleeding (Hemorrhage). ZALTRAP can cause severe internal bleeding including bleeding of the digestive system, brain, or lungs. Signs and symptoms may include blood in the stool or urine, abdominal pain or lightheadedness.